At Midwest Fertility Center https://mfcfamily.com/, we understand how frustrating it can be to struggle with infertility—especially when all the standard tests come back “normal.” For many couples, this leads to a diagnosis called unexplained infertility. It’s a term that can bring more questions than answers, and it affects up to 30% of couples facing fertility challenges.
So, what exactly is unexplained infertility—and what can you do about it?
What Is Unexplained Infertility?
Unexplained infertility is diagnosed when a couple is unable to conceive after 12 months of regular, unprotected intercourse, and all standard fertility evaluations show no clear abnormalities. These tests typically include:
- A semen analysis to assess sperm count, motility, and morphology
- Ovulation monitoring to confirm the woman is releasing eggs regularly
- Hormone tests to evaluate ovarian reserve and thyroid function
- A hysterosalpingogram (HSG) or ultrasound to check the uterus and fallopian tubes
If everything appears normal but conception doesn’t occur, we call it unexplained infertility—not because there isn’t a reason, but because it remains hidden despite thorough evaluation.
Why Can’t We Find the Cause?
At Midwest Fertility Center https://mfcfamily.com/, we want patients to know that “unexplained” doesn’t mean “untreatable.” It simply means that current medical tools haven’t identified a clear cause. Some possibilities include:
- Subtle problems with egg or sperm quality
- Timing issues that don’t align well with ovulation
- Fertilization or implantation issues not visible on tests
- Early embryo development abnormalities
- Immunologic or genetic factors that disrupt conception
These subtle factors can still interfere with fertility, even when routine results appear normal.
What Are the Treatment Options?
Despite the lack of a specific diagnosis, effective treatment is absolutely possible, and we offer a range of options tailored to your age, fertility history, and preferences.
1. Expectant Management
In certain cases, especially for younger couples or those with a shorter time trying to conceive, continued timed intercourse with monitoring may be appropriate for a few months.
2. Ovulation Induction + Intrauterine Insemination (IUI)
Medications such as clomiphene citrate or letrozole can gently stimulate the ovaries to produce more eggs. Combined with IUI, which places prepared sperm directly into the uterus at peak fertility, this approach boosts your chances of success.
3. In Vitro Fertilization (IVF)
IVF offers both the highest pregnancy rates and the ability to closely observe fertilization and embryo development. This can sometimes uncover previously undetected issues and is often the next step if other treatments are unsuccessful or if age is a factor.
4. Lifestyle Guidance
At Midwest Fertility Center https://mfcfamily.com/, we also work with patients to optimize health factors that influence fertility—such as weight, smoking, alcohol use, and stress.
You’re Not Alone—And There Is Hope
One of the most difficult parts of unexplained infertility is the emotional toll of having no clear answers. But it’s important to know that a diagnosis of unexplained infertility does not mean you can’t conceive—many of our patients have gone on to have healthy pregnancies with the right support and treatment plan.
If you’ve been trying to conceive for over a year without success—and especially if your tests have come back normal—you’re not out of options. You just need the right care and a personalized approach.
At Midwest Fertility Center https://mfcfamily.com/, Dr. Madanes and our experienced team are here to walk with you every step of the way. Schedule a consultation today to explore your next steps with confidence.